Epidemic dropsy in India.
نویسندگان
چکیده
Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with Argemone mexicana oil. Sanguinarine and dehydrosanguinarine are two major toxic alkaloids of Argemone oil, which cause widespread capillary dilatation, proliferation and increased capillary permeability. Leakage of the protein-rich plasma component into the extracellular compartment leads to the formation of oedema. The haemodynamic consequences of this vascular dilatation and permeability lead to a state of relative hypovolemia with a constant stimulus for fluid and salt conservation by the kidneys. Illness begins with gastroenteric symptoms followed by cutaneous erythema and pigmentation. Respiratory symptoms such as cough, shortness of breath and orthopnoea progressing to frank right-sided congestive cardiac failure are seen. Mild to moderate anaemia, hypoproteinaemia, mild to moderate renal azotemia, retinal haemorrhages, and glaucoma are common manifestations. There is no specific therapy. Removal of the adulterated oil and symptomatic treatment of congestive cardiac failure and respiratory symptoms, along with administration of antioxidants and multivitamins, remain the mainstay of treatment. Selective cultivation of yellow mustard, strict enforcement of the Indian Food Adulteration Act, and exemplary punishment to unscrupulous traders are the main preventive measures.
منابع مشابه
Changing Pattern of Epidemic Dropsy in North India
Background:Epidemic dropsy occurs due to ingestion of mustard oil contaminated with oil from Argemone mexicana, leading to edema and tenderness of the abdomen, upper and lower limbs. In this study, clinical profiles of patients presented with epidemic dropsy in north India are described. Methods: This was a prospective study of patients presented with epidemic dropsy to the emergency department...
متن کاملSanguinarine, Hydroxybutyrate Dehydrogenase and Fatigue in Epidemic Dropsy: A Retrospective Study of an Outbreak and its Control from Gujarat, India
Objective: We report an outbreak of epidemic dropsy following ingestion of cooking groundnut-oil adulterated with Argemone oil. Methods: We describe 40 patients (18 families) from three towns in Gujarat in 1998, affected with epidemic dropsy during an outbreak and its control measures. They were successfully treated with supportive measures and antioxidants. The outbreak control measures used w...
متن کاملEpidemic Dropsy in Calcutta
This Memoir is a continuation of that by Major Greig, of the same name, numbered 45. It gives a complete history of the recent outbreak of epidemic dropsy in Calcutta, but does not contain much that is new on that subject. There is a valuable note on the outbreak resembling beri-beri which took place in the Basti Jail in 1910, but we do not learn if the disease was beri-beri or epidemic dropsy....
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عنوان ژورنال:
- Postgraduate medical journal
دوره 75 889 شماره
صفحات -
تاریخ انتشار 1999